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Title:
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Phase II Study of Panitumumab, Chemotherapy, and External Beam Radiation in Patients with Locally Advanced Pancreatic Cancer - IRB# 09-088A
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Treatments:
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5 FU, Capecitabine, Gemcitabine, Panitumumab, Radiation Therapy
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Disease Site:
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Gastrointestinal
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Disease SubSite:
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Pancreas
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Drug Provided:
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Panitumumab
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Comments:
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Eligibility:
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Histologically or cytologically confirmed unresectable adenocarcinoma of the pancreas, Including subtotal resection and gross residual disease, No microscopic residual disease only, Measurable disease is not required, Disease is encompassable within standard radiotherapy fields for pancreatic cancer, No evidence of metastatic disease outside of the planned radiotherapy field, No cystadenocarcinoma of the pancreas or pancreatic tumors of neuroendocrine origin, No distant metastases (i.e., liver or lung metastases or peritoneal spread), No history or known presence of CNS metastases, Prior/Concurrent Therapy: More than 21 days since prior laparotomy, No prior anti-epidermal growth factor receptor (EGFR) antibody therapy (e.g., cetuximab), No prior small molecule EGFR inhibitors (e.g., gefitinib, erlotinib, or lapatinib), No prior radiotherapy that would overlap with planned radiotherapy fields, No prior or other concurrent chemotherapy, No prior or other concurrent biologic therapy , More than 4 weeks since prior and no concurrent or planned participation in another experimental drug study except studies with specific interventions intended to treat rashes associated with EGFR agents (e.g., N05C4), No concurrent enteral hyperalimentation, No concurrent chronic immunosuppressive agents (e.g., methotrexate, cyclosporine, or corticosteroids), No concurrent colony-stimulating factors during the first course of therapy, No other concurrent immunotherapy or radiotherapy
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Participating Sites:
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Adventist Medical Center, Northwest Cancer Specialists, Providence Milwaukie Hospital, Providence Portland Medical Center, Providence St. Vincent Medical Center, Southwest Washington Medical Center
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